![]() Among the same 411 differentially expressed proteins in cisplatin-sensitive COC1 cells and cisplain-resistant COC1/DDP cells before and after cisplatin treatment, 14% of them were localized on the cell membrane. There are 710 differential proteins between COC1 and COC1/DDP cells, 783 between COC1 and COC1/DDP cells treated with cisplatin, 917 between the COC1/DDP cells and COC1/DDP cells treated with LaCl3, 775 between COC1/DDP cells treated with cisplatin and COC1/DDP cells treated with cisplatin and LaCl3. We also used KEGG pathway analysis to determine the key signal pathways that those proteins were involved in. Using the GO analysis, we classified those proteins into different subgroups bases on their cellular component, biological process, and molecular function. Using this technique, we determined the differentially expressed proteins in the cisplatin-sensitive ovarian cancer cells COC1 and cisplatin-resistant cells COC1/DDP before and after the application of cisplatin. Label free quantitative proteomics analysis based on the mass spectrometry is widely used. Quantitative proteomics has been made great progress in recent years. Label free quantitative proteomics analysis on the cisplatin resistance in ovarian cancer cells. ![]()
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